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One hypothesis proposes that addicted persons have a drive to achieve a sense of well-being and to overcome depression. Some addicted persons seem to have an abnormal metabolism of NEUROTRANSMITTERS, chemicals that carry signals from one nerve cell to another cell. A primary example is the link between depression and low levels of the brain chemical serotonin and the correlation between high-sugar, high-fat diets, and high brain serotonin levels. Evidence suggests that eating certain sugary foods stimulates the production of brain peptides (ENDORPHINS), which trigger pleasant feelings. It has been hypothesized that the formation of endorphins may be abnormal in some individuals,
possibly triggering compulsive eating behavior like BULIMIA NERVOSA. (See also APPETITE; BLOOD SUGAR; NATURAL SWEETENERS.)